Hydrazine hydrate (1:1) → HCID 69828295, compound

HRID 1839239Notes

Reaction equation

HRID 1839239 reaction equation
CO[C:3]([C@@H:5]1[C@@H:12]2[C@@H:8]([O:9][C:10]([CH3:14])([CH3:13])[O:11]2)[C@H:7]([N:15]2[CH:23]=[N:22][C:21]3[C:16]2=[N:17][CH:18]=[N:19][C:20]=3[NH:24][CH:25]2[CH2:29][CH2:28][CH2:27][CH2:26]2)[O:6]1)=[O:4].O.[NH2:31][NH2:32]>CO>[CH:25]1([NH:24][C:20]2[N:19]=[CH:18][N:17]=[C:16]3[C:21]=2[N:22]=[CH:23][N:15]3[C@H:7]2[C@@H:8]3[O:9][C:10]([CH3:14])([CH3:13])[O:11][C@@H:12]3[C@@H:5]([C:3]([NH:31][NH2:32])=[O:4])[O:6]2)[CH2:29][CH2:28][CH2:27][CH2:26]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 69827870HCID 69827870, compound

Product 1

HCID 69828295HCID 69828295, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of (3aS,4S,6R,6aR)-6-(6-cyclopentylamino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid methyl ester (0.48 g) and hydrazine hydrate (0.29 ml) in methanol (10 ml) was heated at reflux for 28 h. After cooling to room temperature, the mixture was concentrated in vacuo and the residue evaporated twice with dichloromethane (2×20 ml) to give the title compound as a white solid (0.49 g).

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 28 h
  3. concentrationthe mixture was concentrated in vacuo
  4. customthe residue evaporated twice with dichloromethane (2×20 ml)

Sources & evidence

ORD record
ord-a17857437518480dbd1106c0be946713
Source dataset
uspto-grants-2004_01
Patent number
US06677316B2

Reaction notes

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