Hydrazine hydrate (1:1) → HCID 69827444, compound

HRID 1839242Notes

Reaction equation

HRID 1839242 reaction equation
CO[C:3]([C@@H:5]1[C@@H:12]2[C@@H:8]([O:9][C:10]([CH3:14])([CH3:13])[O:11]2)[C@H:7]([N:15]2[CH:23]=[N:22][C:21]3[C:16]2=[N:17][CH:18]=[N:19][C:20]=3[NH:24][CH:25]([CH3:27])[CH3:26])[O:6]1)=[O:4].O.[NH2:29][NH2:30]>CO>[CH:25]([NH:24][C:20]1[N:19]=[CH:18][N:17]=[C:16]2[C:21]=1[N:22]=[CH:23][N:15]2[C@H:7]1[C@@H:8]2[O:9][C:10]([CH3:14])([CH3:13])[O:11][C@@H:12]2[C@@H:5]([C:3]([NH:29][NH2:30])=[O:4])[O:6]1)([CH3:26])[CH3:27]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 69827563HCID 69827563, compound

Product 1

HCID 69827444HCID 69827444, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of (3aS,4S,6R,6aR)-6-(6-isopropylamino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid methyl ester (3.76 g) and hydrazine hydrate (1.26 ml) in methanol (140 ml) was heated under reflux for 48 h. After cooling to room temperature, the mixture was concentrated in vacuo and the residue triturated with ethyl acetate to afford the title compound as a white solid (3.3 g).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 48 h
  3. concentrationthe mixture was concentrated in vacuo
  4. customthe residue triturated with ethyl acetate

Sources & evidence

ORD record
ord-413624052983497b96c92e01572904ab
Source dataset
uspto-grants-2004_01
Patent number
US06677316B2

Reaction notes

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