Potassium Carbonate → HCID 23449123, compound

HRID 1839296Notes

Reaction equation

HRID 1839296 reaction equation
C([O:4][CH2:5][C:6]([C:8]1[N:9]=[CH:10][N:11]2[CH:15]=[CH:14][S:13][C:12]=12)=[O:7])(=O)C.C(=O)([O-])[O-].[K+].[K+]>CO.O>[OH:4][CH2:5][C:6]([C:8]1[N:9]=[CH:10][N:11]2[CH:15]=[CH:14][S:13][C:12]=12)=[O:7]

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 23449267HCID 23449267, compound

Product 1

HCID 23449123HCID 23449123, compoundYield 94.1%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

7-Acetoxyacetylimidazo[5,1-b]thiazole (24.6 mg) was dissolved in 2 ml of methanol and 0.5 ml of water. Potassium carbonate (17.3 mg) was added under ice cooling to the solution. The mixture was stirred for 45 min. Methanol was removed by distillation under the reduced pressure. Water (10 ml) was added to the residue, followed by extraction five times with dichloromethane. The extract was dried over anhydrous magnesium sulfate, and then filtered. The solvent was removed by distillation under the reduced pressure to give 18.8 mg of 7-hydroxyacetylimidazo[5,1-b]thiazole.

Workup

  1. customMethanol was removed by distillation under the reduced pressure
  2. additionWater (10 ml) was added to the residue
  3. extractionfollowed by extraction five times with dichloromethane
  4. dry with materialThe extract was dried over anhydrous magnesium sulfate
  5. filtrationfiltered
  6. customThe solvent was removed by distillation under the reduced pressure

Sources & evidence

ORD record
ord-ff6d89995f1f44cfaf5a5acd5c7fd389
Source dataset
uspto-grants-2004_01
Patent number
US06677331B2

Reaction notes

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