Ammonia methanol → 7-Sulfamoylimidazo[5,1-b]thiazole

HRID 1839312Notes

Reaction equation

HRID 1839312 reaction equation
[NH3:1].CO.Cl[S:5]([C:8]1[N:9]=[CH:10][N:11]2[CH:15]=[CH:14][S:13][C:12]=12)(=[O:7])=[O:6]>C1COCC1>[S:5]([C:8]1[N:9]=[CH:10][N:11]2[CH:15]=[CH:14][S:13][C:12]=12)(=[O:7])(=[O:6])[NH2:1]

Participants

4

Reactant 2

HCID 21705897Ammonia methanolHCID 234490387-Chlorosulfonylimidazo[5,1-b]thiazole

Product 1

HCID 234491397-Sulfamoylimidazo[5,1-b]thiazole

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A 2 M ammonia/methanol solution, (4 ml) was added to a solution of 0.44 g of 7-chlorosulfonylimidazo[5,1-b]thiazole in 10 ml of THF. The mixture was stirred at room temperature for 12 hr. The reaction mixture was concentrated. The residue was purified by column chromatography on silica gel (dichloromethane:methanol=10:1) to give 0.34 g of 7-sulfamoylimidazo[5,1-b]thiazole.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customThe residue was purified by column chromatography on silica gel (dichloromethane:methanol=10:1)

Sources & evidence

ORD record
ord-a54c390459e14ef497080825af863b89
Source dataset
uspto-grants-2004_01
Patent number
US06677331B2

Reaction notes

Loading…