反应详情

A mixture of [3-(1H-indol-4-yl)-phenyl]-acetic acid (4 g, 15.9 mmol), 4N HCl (20 drops) in methanol (30 mL) and dioxane was stirred at rt for 4 hours. The reaction was concentrated, diluted in ethyl acetate, washed with NaHCO3 (2×), brine (2×), dried and concentrated to give 3.72 g (88%) of [3-(1H-Indol-4-yl)-phenyl]-acetic acid methyl ester.

1. concentrationThe reaction was concentrated
2. additiondiluted in ethyl acetate
3. washwashed with NaHCO3 (2×), brine (2×)
4. customdried
5. concentrationconcentrated