Aluminium lithium hydride → HCID 22561945, compound

HRID 1839665Notes

Reaction equation

HRID 1839665 reaction equation
[N:1]1([C:6](=O)[CH2:7][CH:8]2[CH2:16][CH2:15][CH2:14][C:13]3[N:12](S(C4C=CC(C)=CC=4)(=O)=O)[CH:11]=[CH:10][C:9]2=3)[CH2:5][CH2:4][CH2:3][CH2:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>C1COCC1>[N:1]1([CH2:6][CH2:7][CH:8]2[CH2:16][CH2:15][CH2:14][C:13]3[NH:12][CH:11]=[CH:10][C:9]2=3)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 22561821HCID 22561821, compound

Product 1

HCID 22561945HCID 22561945, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Pyrrolidin-1-yl-2-[1-(toluene-4-sulfonyl)-4,5,6,7-tetrahydro-1H-indol-4-yl]-ethanone (840 mg) was reduced using lithium aluminum hydride (4 eq.) in THF (80 mL) at reflux for 5 hours to give 480 mg of mainly 4-(2-pyrrolidin-1-yl-ethyl)-4,5,6,7-tetrahydro-1H-indole as an oil.

Workup

  1. temperatureat reflux for 5 hours

Sources & evidence

ORD record
ord-5a23f24bcd9d495a91dfae8747268d75
Source dataset
uspto-grants-2004_01
Patent number
US06677368B2

Reaction notes

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