1-Methyl-4-piperidone → HCID 20761743, compound

HRID 1839669Notes

Reaction equation

HRID 1839669 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[NH:7][C:8]([CH3:12])=[CH:9][C:10]=1[CH3:11])=[O:5])[CH3:2].[CH3:13][N:14]1[CH2:19][CH2:18][C:17](=O)[CH2:16][CH2:15]1>C(O)(=O)C.C(O)(C(F)(F)F)=O>[CH2:1]([O:3][C:4]([C:6]1[NH:7][C:8]([CH3:12])=[C:9]([C:17]2[CH2:18][CH2:19][N:14]([CH3:13])[CH2:15][CH:16]=2)[C:10]=1[CH3:11])=[O:5])[CH3:2]

Participants

5

Reactant 2

HCID 740491-Methyl-4-piperidoneHCID 1374771H-Pyrrole-2-carboxylic acid, 3,5-dimethyl-, ethyl ester

Product 1

HCID 20761743HCID 20761743, compoundYield 85.4%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 6422Trifluoroacetic acidSolvent

Conditions

Temperature
95 °C

Procedure

To a solution of 3,5-dimethyl-1H-pyrrole-2-carboxylic acid ethyl ester (836 mg, 5 mmol) in acetic acid (10 mL) and TFA (5 mL) under nitrogen was added 1-methyl-piperidin-4-one (0.8 mL, 6.67 mmol). The mixture was then heated in a 95° C. oil bath for overnight. The reaction was concentrated, dissolved in ethyl acetate, washed with NaHCO3, brine, dried and concentrated. The residue was purified on a silica gel column to give 1.12 g (85%) of 3,5-dimethyl-4-(1-methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-1H-pyrrole-2-carboxylic acid ethyl ester.

Workup

  1. concentrationThe reaction was concentrated
  2. dissolutiondissolved in ethyl acetate
  3. washwashed with NaHCO3, brine
  4. customdried
  5. concentrationconcentrated
  6. customThe residue was purified on a silica gel column

Sources & evidence

ORD record
ord-3e4c9becdadf451eb966904ed195f9ed
Source dataset
uspto-grants-2004_01
Patent number
US06677368B2

Reaction notes

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