1,2-Dichloroethane → 2-[4-(2,3-Difluoro-phenyl)-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-5-methyl-1H-pyrrole-3-carboxylic Acid (2-Hydroxy-3-pyrrolidin-1-yl-propyl)-methyl-amide

HRID 1839824노트

반응식

HRID 1839824 반응식
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:10]=1/[C:11](=[CH:19]/[C:20]1[NH:21][C:22]([CH3:28])=[CH:23][C:24]=1[C:25](O)=[O:26])/[C:12](=[O:18])[NH:13]2.[CH3:29][NH:30][CH2:31][CH:32]([OH:39])[CH2:33][N:34]1[CH2:38][CH2:37][CH2:36][CH2:35]1.C(Cl)CCl.C1C=CC2N(O)N=NC=2C=1>CN(C=O)C>[OH:39][CH:32]([CH2:33][N:34]1[CH2:35][CH2:36][CH2:37][CH2:38]1)[CH2:31][N:30]([CH3:29])[C:25]([C:24]1[CH:23]=[C:22]([CH3:28])[NH:21][C:20]=1/[CH:19]=[C:11]1\[C:12](=[O:18])[NH:13][C:14]2[C:10]\1=[C:9]([C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([F:8])[C:2]=1[F:1])[CH:17]=[CH:16][CH:15]=2)=[O:26]

참가 물질

6

반응물 4

HCID 111,2-DichloroethaneHCID 757711-HydroxybenzotriazoleHCID 225620281-(Methylamino)-3-(pyrrolidin-1-yl)propan-2-olHCID 600615542-[4-(2,3-Difluoro-phenyl)-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl)-5-methyl-1H-pyrrole-3-carboxylic acid

생성물 1

HCID 600613862-[4-(2,3-Difluoro-phenyl)-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-5-methyl-1H-pyrrole-3-carboxylic Acid (2-Hydroxy-3-pyrrolidin-1-yl-propyl)-methyl-amide

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

2-[4-(2,3-Difluoro-phenyl)-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-5-methyl-1H-pyrrole-3-carboxylic acid (115 mg, 0.3 mmol) was coupled with 1-methylamino-3-pyrrolidin-1-yl-propan-2-ol (3 eq.), EDC (2 eq.), HOBt (1 eq.) in DMF (1.5 mL) to give 108 mg of the titled compound as a yellow solid. MS 521.2 [M++1].

출처 및 근거

ORD 기록
ord-3ace12aca4a74cf998ce7e842e9ab86d
출처 데이터셋
uspto-grants-2004_01
특허 번호
US06677368B2

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