Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,2-Dichloroethane → 2-[4-(2,3-Difluoro-phenyl)-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-5-methyl-1H-pyrrole-3-carboxylic Acid (2-Hydroxy-3-pyrrolidin-1-yl-propyl)-methyl-amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,2-Dichloroethane | HCID 11 | — |
| 반응물 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 반응물 | 1-(Methylamino)-3-(pyrrolidin-1-yl)propan-2-ol | HCID 22562028 | — |
| 반응물 | 2-[4-(2,3-Difluoro-phenyl)-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl)-5-methyl-1H-pyrrole-3-carboxylic acid | HCID 60061554 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-[4-(2,3-Difluoro-phenyl)-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-5-methyl-1H-pyrrole-3-carboxylic Acid (2-Hydroxy-3-pyrrolidin-1-yl-propyl)-methyl-amide | HCID 60061386 | — |
반응 단계
2-[4-(2,3-Difluoro-phenyl)-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-5-methyl-1H-pyrrole-3-carboxylic acid (115 mg, 0.3 mmol) was coupled with 1-methylamino-3-pyrrolidin-1-yl-propan-2-ol (3 eq.), EDC (2 eq.), HOBt (1 eq.) in DMF (1.5 mL) to give 108 mg of the titled compound as a yellow solid. MS 521.2 [M++1].
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06677368B2 |
| 출처 데이터셋 | uspto-grants-2004_01 |
| ORD ID | ord-3ace12aca4a74cf998ce7e842e9ab86d |
| 출처 메모 | uspto-grants-2004_01 |