HRID1839833

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(=O)N1CCC(C(=O)N2CCCCc3[nH]c(C=O)cc32)CC1

HCID22561749

未命名化合物

HCID22561756

未命名化合物

PRODUCTS

生成物

$结构：CC(=O)N1CCC(C(=O)N2CCCCc3[nH]c(/C=C4\C(=O)Nc5cccc(-c6cccc(F)c6)c54)cc32)CC1$

HCID22561776

未命名化合物

收率 53.9%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID8082

Piperidine

C5H11N

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

4-(1-Acetyl-piperidine-4-carbonyl)-1,4,5,6,7,8-hexahydro-pyrrolo[3,2-b]azepine-2-carbaldehyde (56 mg) was condensed with 4-(3-fluoro-phenyl)-1,3-dihydro-indol-2-one (40 mg) and piperidine (2 drops) in ethanol (1 mL) at rt for overnight. The solvent was concentrated and the residue was purified on a silica gel column to give 50 mg of the title compound as a yellow solid.

WORKUP

后处理

concentrationThe solvent was concentrated
customthe residue was purified on a silica gel column

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bad46d756dc94eb5b28da35a8c992790
来源数据集: uspto-grants-2004_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06677368B2
来源说明: uspto-grants-2004_01

反应 SMILES

[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([C:10]([N:12]2[CH2:18][CH2:17][CH2:16][CH2:15][C:14]3[NH:19][C:20]([CH:22]=O)=[CH:21][C:13]2=3)=[O:11])[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[F:24][C:25]1[CH:26]=[C:27]([C:31]2[CH:39]=[CH:38][CH:37]=[C:36]3[C:32]=2[CH2:33][C:34](=[O:40])[NH:35]3)[CH:28]=[CH:29][CH:30]=1>N1CCCCC1.C(O)C>[C:1]([N:4]1[CH2:5][CH2:6][CH:7]([C:10]([N:12]2[CH2:18][CH2:17][CH2:16][CH2:15][C:14]3[NH:19][C:20](/[CH:22]=[C:33]4\[C:34](=[O:40])[NH:35][C:36]5[C:32]\4=[C:31]([C:27]4[CH:28]=[CH:29][CH:30]=[C:25]([F:24])[CH:26]=4)[CH:39]=[CH:38][CH:37]=5)=[CH:21][C:13]2=3)=[O:11])[CH2:8][CH2:9]1)(=[O:3])[CH3:2]