Aluminium lithium hydride → HCID 69741629, compound

HRID 1839840Notes

Reaction equation

HRID 1839840 reaction equation
[CH:1]1([NH:4][C:5]([C@H:7]2[CH2:11][C@@H:10]([OH:12])[CH2:9][NH:8]2)=O)[CH2:3][CH2:2]1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[CH:1]1([NH:4][CH2:5][C@@H:7]2[NH:8][CH2:9][C@H:10]([OH:12])[CH2:11]2)[CH2:2][CH2:3]1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 28943484(2R,4R)-4-hydroxy-pyrrolidine-2-carboxylic acid cyclopropylamide

Product 1

HCID 69741629HCID 69741629, compoundYield 36.3%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

(2R,4R)-4-Hydroxy-pyrrolidine-2-carboxylic acid cyclopropylamide (3 g) was reduced using LAH (2 g) in THF (150 mL) to give 1 g of (3R,5R)-5-cyclopropylaminomethyl-pyrrolidin-3-ol.

Sources & evidence

ORD record
ord-c32683831be941fb9b1c6cd2517ca032
Source dataset
uspto-grants-2004_01
Patent number
US06677368B2

Reaction notes

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