Sodium Carbonate → HCID 86586547, compound

HRID 1839846Notes

Reaction equation

HRID 1839846 reaction equation
[OH:1][C:2]1[C:11]2C(=CC=[CH:9][CH:10]=2)OC(=O)C=1.Cl.ON.[C:16](=[O:19])([O-:18])[O-:17].[Na+:20].[Na+]>CCCCO>[C:16]([O-:19])([O-:18])=[O:17].[Na+:20].[Na+:20].[CH3:9][CH2:10][CH2:11][CH2:2][OH:1]

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 546829304-Hydroxycoumarin

Product 1

HCID 86586547HCID 86586547, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

4-Hydroxy-coumarin (10 grams), was added to the mixture of hydroxyl-amine hydrochloride (15 grams) and sodium carbonate (23 grams) in n-BuOH (100 mL). The reaction mixture was than heated to reflux and the reflux was maintained for about 13 hours. The reaction mixture was concentrated on rotavapor and the residue was washed with water and dried at about 60° C. The product weighs about 8.56 grams (yield: about 80% w/w).

Workup

  1. temperaturethan heated
  2. temperatureto reflux
  3. temperaturethe reflux was maintained for about 13 hours
  4. concentrationThe reaction mixture was concentrated on rotavapor
  5. washthe residue was washed with water
  6. customdried at about 60° C

Sources & evidence

ORD record
ord-0644c1514546457ea3f81457639cd67e
Source dataset
uspto-grants-2004_01
Patent number
US06677458B2

Reaction notes

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