反应详情

4-Hydroxy-coumarin (10 grams), was added to the mixture of hydroxyl-amine hydrochloride (15 grams) and sodium carbonate (23 grams) in n-BuOH (100 mL). The reaction mixture was than heated to reflux and the reflux was maintained for about 13 hours. The reaction mixture was concentrated on rotavapor and the residue was washed with water and dried at about 60° C. The product weighs about 8.56 grams (yield: about 80% w/w).

1. temperaturethan heated
2. temperatureto reflux
3. temperaturethe reflux was maintained for about 13 hours
4. concentrationThe reaction mixture was concentrated on rotavapor
5. washthe residue was washed with water
6. customdried at about 60° C