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Succinic anhydride → Artesunate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Succinic anhydride | HCID 7922 | — |
| 反応物 | (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal | HCID 107526 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 反応物 | Qing Hau Sau | HCID 9838675 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | Artesunate | HCID 6917864 | — |
反応手順
Artemisinin (500 mg) and polyhydroxy compound (dextrose, 2 g) are stirred in dioxan (15 ml) for 5 minutes. Sodium borohydride (2.4 gm) is added slowly and the reaction mixture is stirred for 2 hours at room temperature (20-30 degree C.). After completion of the reduction step succinic anhydride (250 mg) and sodium bicarbonate (3.5 g) are added and the reaction mixture is further stirred for 2 hours. After usual workup and purification of impure reaction product (650 mg), 89.6% w/w pure artesunic acid is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06677463B1 |
| 出典データセット | uspto-grants-2004_01 |
| ORD ID | ord-69355f58753843b9a01f7d3ff5de6bcd |
| 出典メモ | uspto-grants-2004_01 |