反应详情

Artemisinin (500 mg) and polyhydroxy compound (dextrose, 2 g) are stirred in dioxan (15 ml) for 5 minutes. Sodium borohydride (2.4 gm) is added slowly and the reaction mixture is stirred for 2 hours at room temperature (20-30 degree C.). After completion of the reduction step succinic anhydride (250 mg) and sodium bicarbonate (3.5 g) are added and the reaction mixture is further stirred for 2 hours. After usual workup and purification of impure reaction product (650 mg), 89.6% w/w pure artesunic acid is obtained.

1. stirringthe reaction mixture is further stirred for 2 hours
2. customAfter usual workup and purification of impure reaction product (650 mg)