Hydrochloric Acid → HCID 69637521, compound

HRID 1840229Notes

Reaction equation

HRID 1840229 reaction equation
[OH:1][CH:2]([CH2:15][NH:16][CH:17]([CH3:19])[CH3:18])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12]([O-:14])=[O:13])=[CH:7][CH:6]=1.[ClH:20]>>[ClH:20].[OH:1][CH:2]([CH2:15][NH:16][CH:17]([CH3:19])[CH3:18])[CH2:3][O:4][C:5]1[CH:6]=[CH:7][C:8]([CH2:11][C:12]([OH:14])=[O:13])=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 23447011HCID 23447011, compound

Product 1

HCID 69637521HCID 69637521, compound

Procedure

4-[2-hydroxy-3-[(1-methylethyl)amino]-propoxy]phenylacetate (563 mg, 2.00 mmol) in 6 M hydrochloric acid (15 ml) was heated at 100° C. for 4 h. The reaction mixture was concentrated (rotavapor) and the residue was taken up in water and lyophilised. 1H and 13C NMR spectra were in accordance with the structure and MALDI mass spectrometry gave a M+H at 268 as expected.

Workup

  1. concentrationThe reaction mixture was concentrated (rotavapor)
  2. customgave a M+H at 268

Sources & evidence

ORD record
ord-52288b462490445cbe89d512cc06625f
Source dataset
uspto-grants-2004_01
Patent number
US06680047B2

Reaction notes

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