HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 1-(5-Chloro-2-hydroxyphenyl)piperazine dihydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | HCID 2735754 | HCID 2735754 | — |
| Product | 1-(5-Chloro-2-hydroxyphenyl)piperazine dihydrobromide | HCID 23447908 | — |
Reaction Steps
A suspension of 5.5 g of 1-(5-chloro-2-methoxyphenyl)piperazine in 40 mL of 62% hydrobromic acid was stirred at reflux for 30 hours. After cooling to room temperature, the mixture was filtered by suction and the solid was washed on the funnel with acetone affording 6.02 g of the title compound. M.p. >270° C. (ethanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06680319B2 |
| Source dataset | uspto-grants-2004_01 |
| ORD ID | ord-7fe13fab2df94984b9a2a5dea6bc4f53 |
| Source note | uspto-grants-2004_01 |