Hydrogen Bromide → 1-(5-Chloro-2-hydroxyphenyl)piperazine dihydrobromide

HRID 1840284Notes

Reaction equation

HRID 1840284 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:14]C)=[C:6]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:7]=1.[BrH:16]>>[BrH:16].[BrH:16].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:14])=[C:6]([N:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)[CH:7]=1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 2735754HCID 2735754, compound

Product 1

HCID 234479081-(5-Chloro-2-hydroxyphenyl)piperazine dihydrobromide

Procedure

A suspension of 5.5 g of 1-(5-chloro-2-methoxyphenyl)piperazine in 40 mL of 62% hydrobromic acid was stirred at reflux for 30 hours. After cooling to room temperature, the mixture was filtered by suction and the solid was washed on the funnel with acetone affording 6.02 g of the title compound. M.p. >270° C. (ethanol).

Workup

  1. temperatureat reflux for 30 hours
  2. filtrationthe mixture was filtered by suction
  3. washthe solid was washed on the funnel with acetone affording 6.02 g of the title compound

Sources & evidence

ORD record
ord-7fe13fab2df94984b9a2a5dea6bc4f53
Source dataset
uspto-grants-2004_01
Patent number
US06680319B2

Reaction notes

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