Methyl 3-phenyl-4-isoxazolecarboxylate → 3-Phenyl-1,2-oxazole-4-carboxylic acid

HRID 1840298Notes

Reaction equation

HRID 1840298 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([C:13]([OH:15])=[O:14])=[CH:11][O:10][N:9]=2)=[CH:4][CH:3]=1.C1(C2C(C(OC)=O)=CON=2)C=CC=CC=1>>[C:5]1([C:8]2[C:12]([C:13]([OH:15])=[O:14])=[CH:11][O:10][N:9]=2)[CH:4]=[CH:3][CH:2]=[CH:7][CH:6]=1

Participants

3

Reactant 2

HCID 10750662Methyl 3-phenyl-4-isoxazolecarboxylateHCID 234478853-(4-Fluoro-phenyl)-isoxazole-4-carboxylic acid

Product 1

HCID 131522783-Phenyl-1,2-oxazole-4-carboxylic acid

Procedure

This compound was synthesised following the procedure described for Compound 8D but using Compound 15A instead of Compound 8C (90.2%). M.p. 162.7-164.5° C.

Workup

  1. customThis compound was synthesised

Sources & evidence

ORD record
ord-55bb8b2ab8ef49fcb4e0b3a5185a6bdd
Source dataset
uspto-grants-2004_01
Patent number
US06680319B2

Reaction notes

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