Hydrochloric Acid → HCID 69898355, compound

Participants

Reaction Steps

Compound 78 (150 mg, 0.38 mmol) was treated with excess HCl in acetic acid 1 h. Acid removed in vacuo and residue dissolved in methanol and precipitated by addition of ether. The precipitate was dried in vacuum at 100° C. Mp: 172-80° C. IR (KBr) (cm−1): 3000(br), 1700, 1606, 1454. 1H NMR: (DMSO-d6): δ=12.85 (s, 1H, CO2H), 8.95 (s, 2H, NH), 7.92-7.20 (m, 9H, Ar—H), 4.56 (s, 1H, Ar2CH), 3.33 (s, 8H, piperazne-H). Anal. calc. for C18H20N2O2×2HCl, C,58.54; H, 6.00; N, 7.59. Found: C, 59.9; H, 6.47; N, 7.88.

Provenance & Evidence