Hydrochloric Acid → HCID 69898355, compound

HRID 1840310Notes

Reaction equation

HRID 1840310 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH:14]([C:21]2[CH:29]=[CH:28][C:24]([C:25]([OH:27])=[O:26])=[CH:23][CH:22]=2)[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:30]>C(O)(=O)C>[ClH:30].[ClH:30].[N:11]1([CH:14]([C:21]2[CH:22]=[CH:23][C:24]([C:25]([OH:27])=[O:26])=[CH:28][CH:29]=2)[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10786928HCID 10786928, compound

Product 1

HCID 69898355HCID 69898355, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Compound 78 (150 mg, 0.38 mmol) was treated with excess HCl in acetic acid 1 h. Acid removed in vacuo and residue dissolved in methanol and precipitated by addition of ether. The precipitate was dried in vacuum at 100° C. Mp: 172-80° C. IR (KBr) (cm−1): 3000(br), 1700, 1606, 1454. 1H NMR: (DMSO-d6): δ=12.85 (s, 1H, CO2H), 8.95 (s, 2H, NH), 7.92-7.20 (m, 9H, Ar—H), 4.56 (s, 1H, Ar2CH), 3.33 (s, 8H, piperazne-H). Anal. calc. for C18H20N2O2×2HCl, C,58.54; H, 6.00; N, 7.59. Found: C, 59.9; H, 6.47; N, 7.88.

Workup

  1. customAcid removed in vacuo and residue
  2. dissolutiondissolved in methanol
  3. customprecipitated by addition of ether
  4. customThe precipitate was dried in vacuum at 100° C

Sources & evidence

ORD record
ord-1d3d47390afd4c31b0ae863f6753497d
Source dataset
uspto-grants-2004_01
Patent number
US06680321B1

Reaction notes

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