反应详情

N,N-Diisopropylethylamine (4.35 ml) and 1.70 ml of methanesulfonyl chloride were added to a suspension of 1.22 ml of 2-hydroxyethyl disulfide in 30 ml of dichloromethane at −40° C. under an argon atmosphere. The mixture was stirred at that temperature for 30 min. The reaction solution was then diluted with dichloromethane, and the diluted solution was washed with an dilute aqueous hydrochloric acid solution, an aqueous sodium hydrogencarbonate solution, and water in that order, and was dried over anhydrous magnesium sulfate. The solvent was removed by distillation under the reduced pressure to prepare 3.08 g of 2-methanesulfonyloxyethyl disulfide.

1. washthe diluted solution was washed with an dilute aqueous hydrochloric acid solution
2. dry with materialan aqueous sodium hydrogencarbonate solution, and water in that order, and was dried over anhydrous magnesium sulfate
3. customThe solvent was removed by distillation under the reduced pressure
4. customto prepare 3.08 g of 2-methanesulfonyloxyethyl disulfide