反应详情

温度

95 °C

A mixture of 5-chloro-2-oxindole (167 mg), 3-methyl-indole-2-carbaldehyde (190 mg) (prepared according to Synthetic Communications, 1986, 16, 1799) and piperidine (10 mg) in ethanol was heated in a sealed tube at 95° C. for 4 hours. The mixture was cooled to room temperature. The solid was collected by vacuum filtration, washed with cold ethanol and dried in vacuum oven for overnight to give 5-chloro-3-(3-methyl-1H-indol-2-ylmethylene)-1,3-dihydro-indol-2-one.

1. temperatureThe mixture was cooled to room temperature
2. filtrationThe solid was collected by vacuum filtration
3. washwashed with cold ethanol
4. customdried in vacuum oven for overnight