1-(3-Bromopropoxy)-4-chlorobenzene → 1-Acetylsulfanyl-3-(4-chlorophenoxy)propane

Participants

Reaction Steps

A solution of Intermediate 2 (6.0 g) in DMF (50 ml) was treated with potassium thioacetate (5.7 g) at room temperature for 3 h, then the brown solution was added to 5% sodium bicarbonate solution and extracted with ether (3×200 ml). The solvent was washed with water (200 ml) and brine, dried over MgSO4 and evaporated to give the title compound (5.50 g) as a beige solid.

Provenance & Evidence