反应详情

A solution of Intermediate 2 (6.0 g) in DMF (50 ml) was treated with potassium thioacetate (5.7 g) at room temperature for 3 h, then the brown solution was added to 5% sodium bicarbonate solution and extracted with ether (3×200 ml). The solvent was washed with water (200 ml) and brine, dried over MgSO4 and evaporated to give the title compound (5.50 g) as a beige solid.

1. extractionextracted with ether (3×200 ml)
2. washThe solvent was washed with water (200 ml) and brine
3. dry with materialdried over MgSO4
4. customevaporated