Hydrochloric Acid → HCID 86590132, compound

Participants

Reaction Steps

A solution of 1.54 g (3.0 mmol) of phenylmethyl (S)-4-[4-[[(1,1-dimethylethoxy)carbonyl]amino]-5-(4-ethylpiperid-1-yl)-5-oxopentyl]piperidine-1-carboxylate in 60 ml of dichloromethane is treated for 5 min at 0° C. with a stream of hydrogen chloride. After 3 hours at 0° C., the mixture is concentrated under reduced pressure. The resulting product is used without further purification in the following step. 1.35 g of phenylmethyl (S)-4-[4-amino-5-(4-ethylpiperid-1-yl)-5-oxopentyl]piperidine-1-carboxylate hydrochloride are thus obtained in the form of a viscous oil.

Provenance & Evidence