Hydrochloric Acid → HCID 86590132, compound

HRID 1840519Notes

Reaction equation

HRID 1840519 reaction equation
CC(C)(OC([NH:7][C@H:8]([C:28]([N:30]1[CH2:35][CH2:34][CH:33]([CH2:36][CH3:37])[CH2:32][CH2:31]1)=[O:29])[CH2:9][CH2:10][CH2:11][CH:12]1[CH2:17][CH2:16][N:15]([C:18]([O:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[O:19])[CH2:14][CH2:13]1)=O)C.[ClH:39]>ClCCl>[ClH:39].[NH2:7][C@H:8]([C:28]([N:30]1[CH2:35][CH2:34][CH:33]([CH2:36][CH3:37])[CH2:32][CH2:31]1)=[O:29])[CH2:9][CH2:10][CH2:11][CH:12]1[CH2:17][CH2:16][N:15]([C:18]([O:20][CH2:21][C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)=[O:19])[CH2:14][CH2:13]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86590131HCID 86590131, compound

Product 1

HCID 86590132HCID 86590132, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 1.54 g (3.0 mmol) of phenylmethyl (S)-4-[4-[[(1,1-dimethylethoxy)carbonyl]amino]-5-(4-ethylpiperid-1-yl)-5-oxopentyl]piperidine-1-carboxylate in 60 ml of dichloromethane is treated for 5 min at 0° C. with a stream of hydrogen chloride. After 3 hours at 0° C., the mixture is concentrated under reduced pressure. The resulting product is used without further purification in the following step. 1.35 g of phenylmethyl (S)-4-[4-amino-5-(4-ethylpiperid-1-yl)-5-oxopentyl]piperidine-1-carboxylate hydrochloride are thus obtained in the form of a viscous oil.

Workup

  1. concentrationthe mixture is concentrated under reduced pressure
  2. customThe resulting product is used without further purification in the following step

Sources & evidence

ORD record
ord-084ac4f721cd44c586f49bc345eb76d8
Source dataset
uspto-grants-2004_01
Patent number
US06680329B2

Reaction notes

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