HCID 23448162, compound → HCID 69820511, compound

HRID 1840525Notes

Reaction equation

HRID 1840525 reaction equation
O=C(N(C(=O)CC)C1C(C2CCCC2)=CC=CC=1S([Cl:20])(=O)=O)CC.Cl.N[C@@H](CCCC1C=NC(N)=CN=1)C(N1CCC(=C(F)F)CC1)=O.[NH2:49][C:50]1[N:51]=[CH:52][C:53]([CH2:56][CH2:57][CH2:58][C@H:59]([NH:71][S:72]([C:75]2[CH:80]=[CH:79][CH:78]=[C:77]([CH:81]3[CH2:85][CH2:84][CH2:83][CH2:82]3)[C:76]=2[NH:86][C:87](=[O:90])[CH2:88][CH3:89])(=[O:74])=[O:73])[C:60]([N:62]2[CH2:67][CH2:66][C:65](=[C:68]([F:70])[F:69])[CH2:64][CH2:63]2)=[O:61])=[N:54][CH:55]=1>>[ClH:20].[NH2:49][C:50]1[N:51]=[CH:52][C:53]([CH2:56][CH2:57][CH2:58][C@H:59]([NH:71][S:72]([C:75]2[CH:80]=[CH:79][CH:78]=[C:77]([CH:81]3[CH2:85][CH2:84][CH2:83][CH2:82]3)[C:76]=2[NH:86][C:87](=[O:90])[CH2:88][CH3:89])(=[O:74])=[O:73])[C:60]([N:62]2[CH2:63][CH2:64][C:65](=[C:68]([F:69])[F:70])[CH2:66][CH2:67]2)=[O:61])=[N:54][CH:55]=1

Participants

4

Reactant 3

HCID 23448162HCID 23448162, compoundHCID 69820471HCID 69820471, compoundHCID 69820512HCID 69820512, compound

Product 1

HCID 69820511HCID 69820511, compound

Procedure

The process is performed in the same way as in Example 1.6, and, starting with 1.11 g (3.0 mmol) of 2-[bis(1-oxopropyl)amino]-3-cyclopentylbenzenesulphonyl chloride and 1.21 g (3.0 mmol) of (S)-1-[2-amino-5-(5-amino-2-pyrazinyl)-1-oxopentyl]-4-(difluoromethylene)piperidine hydrochloride (2:1), 1.3 g of (S)-N-[2-[[[4-(5-amino-2-pyrazinyl)-1-[[4-(difluoromethylene)piperid-1-yl]carbonyl]butyl]amino]sulphonyl]-6-cyclopentylphenyl]propanamide are obtained.

Workup

  1. customare obtained

Sources & evidence

ORD record
ord-a6f5ef3102c74a3ab9ca5513dd9226c8
Source dataset
uspto-grants-2004_01
Patent number
US06680329B2

Reaction notes

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