4-METHYL-PIPERIDINE HYDROCHLORIDE → HCID 69820426, compound

HRID 1840526Notes

Reaction equation

HRID 1840526 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][CH2:10][C@H:11]([NH:21]C(=O)OC(C)(C)C)[C:12]([N:14]2[CH2:19][CH2:18][CH:17]([CH3:20])[CH2:16][CH2:15]2)=[O:13])=[N:6][CH:7]=1.[ClH:29].CC1CCNCC1>>[ClH:29].[NH2:21][C@@H:11]([CH2:10][CH2:9][CH2:8][C:5]1[CH:4]=[CH:3][C:2]([NH2:1])=[CH:7][N:6]=1)[C:12]([N:14]1[CH2:19][CH2:18][CH:17]([CH3:20])[CH2:16][CH2:15]1)=[O:13]

Participants

3

Reactant 2

HCID 5211194-METHYL-PIPERIDINE HYDROCHLORIDEHCID 131724321HCID 131724321, compound

Product 1

HCID 69820426HCID 69820426, compound

Procedure

The same procedure as in Example 1.5 is used. Thus, starting with 1,1-dimethylethyl [(S)-4-(5-aminopyrid-2-yl)-1-[(4-methylpiperid-1-yl)carbonyl]butyl]carbamate (10.2 g; 26.0 mmol), 9.5 g of 1-[(2S)-2-amino-5-(5-aminopyrid-2-yl)-1-oxopentyl[-4-methylpiperidine hydrochloride are obtained in the form of a hygroscopic amorphous powder, which is used without further purification in the following step.

Workup

  1. customare obtained in the form of a hygroscopic amorphous powder, which
  2. customis used without further purification in the following step

Sources & evidence

ORD record
ord-eb97946480424532ac73c5f453d7e591
Source dataset
uspto-grants-2004_01
Patent number
US06680329B2

Reaction notes

Loading…