Methanol → Methyl 8-[1-[3,5-bis(trifluoromethyl)phenyl]ethyl-methylcarbamoyl]-7-(4-fluoro-2-methylphenyl)-1,8-diazaspiro[4.5]decane-2-carboxylate
Reaction equation
[CH3:1][O:2][C:3](=[O:4])[CH:5]1[NH:6][C:7]2([CH:8]([I:10])[CH2:9]1)[CH2:11][CH:12]([c:36]1[c:37]([CH3:43])[cH:38][c:39]([F:42])[cH:40][cH:41]1)[N:13]([C:16](=[O:17])[N:18]([CH3:19])[CH:20]([CH3:21])[c:22]1[cH:23][c:24]([C:32]([F:33])([F:34])[F:35])[cH:25][c:26]([C:28]([F:29])([F:30])[F:31])[cH:27]1)[CH2:14][CH2:15]2.[CH3:44][CH2:45][N:46]([CH2:47][CH3:48])[CH2:49][CH3:50].[CH3:51][OH:52]>>[CH3:1][O:2][C:3](=[O:4])[CH:5]1[NH:6][C:7]2([CH2:8][CH2:9]1)[CH2:11][CH:12]([c:36]1[c:37]([CH3:43])[cH:38][c:39]([F:42])[cH:40][cH:41]1)[N:13]([C:16](=[O:17])[N:18]([CH3:19])[CH:20]([CH3:21])[c:22]1[cH:23][c:24]([C:32]([F:33])([F:34])[F:35])[cH:25][c:26]([C:28]([F:29])([F:30])[F:31])[cH:27]1)[CH2:14][CH2:15]2Participants
4
Sources & evidence
- ORD record
- ord-675754b27b3a4d0f982ab5b2418025c7
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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