反应详情

15 g (81.8 mmol) of 3-methoxy-4-nitrobenzyl alcohol were hydrogenated over 1.3 g of palladium/carbon (10% strength; 50% water) in 500 mL of methyl tert-butyl ether with ice cooling. After the absorption of hydrogen was complete, the catalyst was filtered off and 10.14 mL (81.8 mmol) of 2-methylphenyl isocyanate were added to the filtrate with stirring in the course of 30 minutes. The reaction mixture was allowed to stand overnight, and the precipitated solid was filtered off with suction and washed with methyl tert-butyl ether. Yield: 20.5 g (88%).

1. customAfter the absorption of hydrogen
2. filtrationthe catalyst was filtered off
3. waitto stand overnight
4. filtrationthe precipitated solid was filtered off with suction
5. washwashed with methyl tert-butyl ether