Hydrochloric Acid → HCID 12044599, compound

HRID 1840621Notes

Reaction equation

[CH3:1][C:2]1([CH3:50])[C:6](=[O:7])[N:5]([C@@H:8]([CH2:25][CH:26]2[CH2:28][CH2:27]2)[C:9]([NH:11][CH:12]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)[CH2:13][C:14]([O:16]CC)=[O:15])=[O:10])[C:4](=[O:29])[N:3]1[CH2:30][C:31]1[CH:36]=[CH:35][C:34]([NH:37][C:38]([NH:40][C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][C:42]=2[CH3:47])=[O:39])=[C:33]([O:48][CH3:49])[CH:32]=1.Cl>>[CH3:1][C:2]1([CH3:50])[C:6](=[O:7])[N:5]([C@@H:8]([CH2:25][CH:26]2[CH2:28][CH2:27]2)[C:9]([NH:11][CH:12]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)[CH2:13][C:14]([OH:16])=[O:15])=[O:10])[C:4](=[O:29])[N:3]1[CH2:30][C:31]1[CH:36]=[CH:35][C:34]([NH:37][C:38]([NH:40][C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][C:42]=2[CH3:47])=[O:39])=[C:33]([O:48][CH3:49])[CH:32]=1

Participants

Reactant 2

HCID 313Hydrochloric Acid2×

HCID 12044598HCID 12044598, compound

Product 1

HCID 12044599HCID 12044599, compound

Procedure

The compound was prepared analogously to Example 10 from 170 mg (0.248 mmol) of the compound of Example 15, but was not converted into the hydrochloride by addition of hydrochloric acid. Yield: 160 mg (98%).

Sources & evidence

ORD record: ord-686c517f84a34eac975335b48a390488
Source dataset: uspto-grants-2004_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06680333B2

Reaction notes

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