HRID1840621

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

2 次

结构：CCOC(=O)CC(NC(=O)[C@H](CC1CC1)N1C(=O)N(Cc2ccc(NC(=O)Nc3ccccc3C)c(OC)c2)C(C)(C)C1=O)c1ccccn1

HCID12044598

未命名化合物

PRODUCTS

生成物

结构：COc1cc(CN2C(=O)N([C@@H](CC3CC3)C(=O)NC(CC(=O)O)c3ccccn3)C(=O)C2(C)C)ccc1NC(=O)Nc1ccccc1C

HCID12044599

未命名化合物

PROCEDURE

实验过程

The compound was prepared analogously to Example 10 from 170 mg (0.248 mmol) of the compound of Example 15, but was not converted into the hydrochloride by addition of hydrochloric acid. Yield: 160 mg (98%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-686c517f84a34eac975335b48a390488
来源数据集: uspto-grants-2004_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06680333B2
来源说明: uspto-grants-2004_01

反应 SMILES

[CH3:1][C:2]1([CH3:50])[C:6](=[O:7])[N:5]([C@@H:8]([CH2:25][CH:26]2[CH2:28][CH2:27]2)[C:9]([NH:11][CH:12]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)[CH2:13][C:14]([O:16]CC)=[O:15])=[O:10])[C:4](=[O:29])[N:3]1[CH2:30][C:31]1[CH:36]=[CH:35][C:34]([NH:37][C:38]([NH:40][C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][C:42]=2[CH3:47])=[O:39])=[C:33]([O:48][CH3:49])[CH:32]=1.Cl>>[CH3:1][C:2]1([CH3:50])[C:6](=[O:7])[N:5]([C@@H:8]([CH2:25][CH:26]2[CH2:28][CH2:27]2)[C:9]([NH:11][CH:12]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)[CH2:13][C:14]([OH:16])=[O:15])=[O:10])[C:4](=[O:29])[N:3]1[CH2:30][C:31]1[CH:36]=[CH:35][C:34]([NH:37][C:38]([NH:40][C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][C:42]=2[CH3:47])=[O:39])=[C:33]([O:48][CH3:49])[CH:32]=1