反应详情

The preparation was carried out analogously to W. Duczek et al., Synthesis, 37-38 (1996). A solution of 4.04 g (40 mmol) of triethylamine in 10 mL of dichloromethane was added at 0° C. to a solution of 8.94 g (40 mmol) of L-leucine tert-butyl ester hydrochloride and 3.4 g (40 mmol) of cyanomethyl formate in 60 mL of dichloromethane. The reaction solution was allowed to warm to room temperature, stirred overnight at room temperature and then washed twice with saturated NaCl solution. The phases were separated and the organic phase was dried over magnesium sulfate. After filtration and removal of the solvent in vacuo, the residue obtained was distilled in vacuo. Yield: 7.5 g (87%). Boiling point: 118° C./2.7 Pa (0.02 torr).

1. customDuczek et al., Synthesis, 37-38 (1996)
2. washwashed twice with saturated NaCl solution
3. customThe phases were separated
4. dry with materialthe organic phase was dried over magnesium sulfate
5. filtrationAfter filtration and removal of the solvent in vacuo
6. customthe residue obtained
7. distillationwas distilled in vacuo