反应详情

温度

10 °C

At 2° C. a solution of 191.99 g (5.079 mol) of sodium borohydride in 520 ml of water and 22 ml of 2N sodium hydroxide solution is added dropwise to a suspension of 1100 g (2.902 mol) of (1) in 22 l of ethyl acetate. The mixture is stirred for 2 hours at 10° C. and then heated to 71° C. The suspension is filtered through Celite and cooled to 0° C. The product that crystallises out is filtered off and dried at 40° C. until a constant weight is attained.

1. temperatureheated to 71° C
2. filtrationThe suspension is filtered through Celite
3. temperaturecooled to 0° C
4. customThe product that crystallises out
5. filtrationis filtered off
6. customdried at 40° C. until a constant weight