反应详情

5.00 g of diethyl aminomalonate hydrochloride and 4.78 g of triethylamine were added to 100 ml of chloroform, and the resulting solution was stirred at the room temperature for 30 minutes. After cooling down the solution to 10° C., 4.13 g of 4-chlorobenzoylchloride was slowly added to the solution and the resulting solution was stirred at the room temperature for 2 hours. Upon the completion of the reaction, the solution was washed with 20 ml of water and 20 ml of 5% sodium bicarbonate and the organic layer was subjected to dry filtration to yield 6.70 g (90.4%) of diethyl 4-chlorobenzamidomalonate.

1. temperatureAfter cooling down the solution to 10° C.
2. stirringthe resulting solution was stirred at the room temperature for 2 hours
3. customUpon the completion of the reaction
4. washthe solution was washed with 20 ml of water and 20 ml of 5% sodium bicarbonate
5. customto dry
6. filtrationfiltration