Water → 2-Difluoromethoxy-6-fluorobenzamidoxime
Reaction equation
[F:1][CH:2]([F:13])[O:3][C:4]1[CH:11]=[CH:10][CH:9]=[C:8]([F:12])[C:5]=1[C:6]#[N:7].Cl.[NH2:15][OH:16].C(=O)([O-])[O-].[Na+].[Na+].O>C(O)C>[F:13][CH:2]([F:1])[O:3][C:4]1[CH:11]=[CH:10][CH:9]=[C:8]([F:12])[C:5]=1[C:6](=[N:15][OH:16])[NH2:7]Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 75 °C
Procedure
A mixture of 6.4 g of 2-difluoromethoxy-6-fluorobenzonitrile and 3.1 g of hydroxylamine hydrochloride, 2.6 g of sodium carbonate, 7 ml of water and 35 ml of ethanol was stirred for 20 hours at 75° C.
Sources & evidence
- ORD record
- ord-544569d37be34e0e8ac9c49a6de4cb24
- Source dataset
- uspto-grants-2004_01
- Patent number
- US06680402B2
Reaction notes
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