Dichloromethane → (2r)-n-Allyloxyethyl-1,2,3,4,5,6-hexahydro-6,11,11-trimethyl-2,6-methano-3-benzazocin-10-ol-hydrochloride

1.8 g of allyloxyacetic acid are placed in 15 mL dichloromethane, combined with 4.8 g of TBTU and 7.5 mL of ethyldiisopropylamine and stirred for 15 min. at RT. Then the mixture is cooled to −5° C. and 3.1 g of 1,2,3,4,5,6-hexahydro-6,11,11-trimethyl-2,6-methano-3-benzazocin-10-ol are added. The mixture is stirred for 30 min at 0° C., and for 1 h at RT. Then it is washed once with 100 ml of 2N HCL and 100ml of 10% potassium carbonate solution, dried and evaporated down in vacuo. The residue is taken up in 50 mL of THF and added dropwise under nitrogen to a suspension of 1.0 g of lithium aluminium hydride in 50 ml of THF (temp. increases to 35° C.). Then the mixture is heated to 50° C., stirred for 1 h, cooled and 1 ml of water is added dropwise at 0-10° C., the mixture is stirred for 30 min, 3 ml of NaOH are added and the mixture is stirred for another 30 min. The precipitate is suction filtered, the mother liquor is evaporated down in vacuo and the residue is filtered through a short column (about 75 ml of silica gel; dichloromethane 70, ethyl acetate 20, methanol 10). The appropriate fractions are evaporated down in vacuo, and crystallised from acetone+eth. HCl. Yield 2.8 g (77%), melting point: 236° C.; [α]D20=−78,3° (c=1; methanol).

1. temperatureThen the mixture is cooled to −5° C.
2. stirringThe mixture is stirred for 30 min at 0° C.
3. waitfor 1 h at RT
4. washThen it is washed once with 100 ml of 2N HCL and 100ml of 10% potassium carbonate solution
5. customdried
6. customevaporated down in vacuo
7. additionadded dropwise under nitrogen to a suspension of 1.0 g of lithium aluminium hydride in 50 ml of THF (temp. increases to 35° C.)
8. temperatureThen the mixture is heated to 50° C.
9. stirringstirred for 1 h
10. temperaturecooled
11. addition1 ml of water is added dropwise at 0-10° C.
12. stirringthe mixture is stirred for 30 min
13. addition3 ml of NaOH are added
14. stirringthe mixture is stirred for another 30 min
15. filtrationfiltered
16. customthe mother liquor is evaporated down in vacuo
17. filtrationthe residue is filtered through a short column (about 75 ml of silica gel; dichloromethane 70, ethyl acetate 20, methanol 10)
18. customThe appropriate fractions are evaporated down in vacuo
19. customcrystallised from acetone+

ORD record

ord-b22a573a48ca408a826946e33df03f52

Source dataset

uspto-grants-2004_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06683089B2