1-Iodooctane → 6-Acetyl-4,4-dimethyl-1-octyl-3,4-dihydroquinolin-2(1H)-one

HRID 1840875Notes

Reaction equation

HRID 1840875 reaction equation
[CH2:1]([N:7]1[C:16]2[C:11](=[CH:12][C:13]([C:17](=[O:19])[CH3:18])=[CH:14][CH:15]=2)[C:10]([CH3:21])([CH3:20])[CH2:9][C:8]1=[O:22])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].I[CH2:24][CH2:25]CCCCCC>>[CH2:1]([N:7]1[C:16]2[C:11](=[CH:12][C:13]([C:17](=[O:19])[CH3:18])=[CH:14][CH:15]=2)[C:10]([CH3:21])([CH3:20])[CH2:9][C:8]1=[O:22])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:24][CH3:25]

Participants

3

Reactant 2

HCID 123801-IodooctaneHCID 121354162(1H)-Quinolinone, 6-acetyl-1-hexyl-3,4-dihydro-4,4-dimethyl-

Product 1

HCID 234447046-Acetyl-4,4-dimethyl-1-octyl-3,4-dihydroquinolin-2(1H)-one

Procedure

Following a procedure similar to that used for the preparation of Intermediate 6a but using 1-iodo-n-octane as the alkylating reagent the title compound was obtained as a colorless oil (86% yield).

Sources & evidence

ORD record
ord-ba6dfb286217485bbdf9cb62cd0fe085
Source dataset
uspto-grants-2004_01
Patent number
US06683092B1

Reaction notes

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