cis-Cinnamic acid → (R)-N-(1-Azabicyclo[2.2.2]oct-3-yl)(Z-3-phenylpropenamide)

HRID 1840893Notes

Reaction equation

HRID 1840893 reaction equation
Cl.Cl.[N:3]12[CH2:10][CH2:9][CH:6]([CH2:7][CH2:8]1)[C@@H:5]([NH2:11])[CH2:4]2.[C:12]1(/[CH:18]=[CH:19]\[C:20](O)=[O:21])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[N:3]12[CH2:10][CH2:9][CH:6]([CH2:7][CH2:8]1)[C@@H:5]([NH:11][C:20](=[O:21])/[CH:19]=[CH:18]\[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH2:4]2

Participants

3

Reactant 2

HCID 5372954cis-Cinnamic acidHCID 12494972(R)-(+)-3-Aminoquinuclidine Dihydrochloride

Product 1

HCID 69684672(R)-N-(1-Azabicyclo[2.2.2]oct-3-yl)(Z-3-phenylpropenamide)

Procedure

Prepared as a free base by a method analogous to that described in Example 1 from (R)-1-azabicyclo[2.2.2]oct-3-ylamine dihydrochloride, and Z-3-phenylpropenoic acid; MS (ES+) 257 (MH+).

Workup

  1. customPrepared as a free base by a method analogous to

Sources & evidence

ORD record
ord-36b1dbe1cb6f47d1acfc207fb775df99
Source dataset
uspto-grants-2004_01
Patent number
US06683090B1

Reaction notes

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