反应详情

To a solution of 0.7 g (1.4 mmol) of 2-[2-(4-{1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1H-indol-3-yl}-piperidin-1-yl)-ethoxy]-benzoic acid methyl ester in 10 mL of methyl alcohol, 10 mL of a solution of methyl alcohol saturated with hydrogen chloride were added. The crude mixture was heated at 70° C. for 1 hour and the solvent was removed under reduced pressure. After addition of 20 mL of water, the crude mixture was neutralised with 2N NaOH and the aqueous phase was extracted with chloroform. After removal of the solvent at reduced pressure 0.5 g of the desired product were obtained.

1. customthe solvent was removed under reduced pressure
2. additionAfter addition of 20 mL of water
3. extractionthe aqueous phase was extracted with chloroform
4. customAfter removal of the solvent at reduced pressure 0.5 g of the desired product
5. customwere obtained