Hydrochloric Acid → HCID 23444865, compound

HRID 1840938Notes

Reaction equation

HRID 1840938 reaction equation
C[O:2][C:3](=[O:37])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[O:10][CH2:11][CH2:12][N:13]1[CH2:18][CH2:17][CH:16]([C:19]2[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[N:21]([CH2:28][CH2:29][O:30]C3CCCCO3)[CH:20]=2)[CH2:15][CH2:14]1.Cl>CO>[OH:30][CH2:29][CH2:28][N:21]1[C:22]2[C:27](=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:19]([CH:16]2[CH2:15][CH2:14][N:13]([CH2:12][CH2:11][O:10][C:5]3[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=3[C:3]([OH:37])=[O:2])[CH2:18][CH2:17]2)=[CH:20]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 53821643HCID 53821643, compound

Product 1

HCID 23444865HCID 23444865, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To a solution of 0.7 g (1.4 mmol) of 2-[2-(4-{1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1H-indol-3-yl}-piperidin-1-yl)-ethoxy]-benzoic acid methyl ester in 10 mL of methyl alcohol, 10 mL of a solution of methyl alcohol saturated with hydrogen chloride were added. The crude mixture was heated at 70° C. for 1 hour and the solvent was removed under reduced pressure. After addition of 20 mL of water, the crude mixture was neutralised with 2N NaOH and the aqueous phase was extracted with chloroform. After removal of the solvent at reduced pressure 0.5 g of the desired product were obtained.

Workup

  1. customthe solvent was removed under reduced pressure
  2. additionAfter addition of 20 mL of water
  3. extractionthe aqueous phase was extracted with chloroform
  4. customAfter removal of the solvent at reduced pressure 0.5 g of the desired product
  5. customwere obtained

Sources & evidence

ORD record
ord-cd3685882f6a44fea06581ef94ed9512
Source dataset
uspto-grants-2004_01
Patent number
US06683096B2

Reaction notes

Loading…