1-Bromo-2-Chloroethane → HCID 53946192, compound

HRID 1840949Notes

Reaction equation

HRID 1840949 reaction equation
[CH2:1]([O:3][C:4](=[O:13])[C:5]1[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:6]=1[OH:12])[CH3:2].Br[CH2:15][CH2:16][Cl:17].C(=O)([O-])[O-].[K+].[K+]>>[CH2:1]([O:3][C:4](=[O:13])[C:5]1[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:6]=1[O:12][CH2:15][CH2:16][Cl:17])[CH3:2]

Participants

4

Reactant 3

HCID 78491-Bromo-2-ChloroethaneHCID 11430Potassium CarbonateHCID 118629Ethyl 5-methylsalicylate

Product 1

HCID 53946192HCID 53946192, compound

Procedure

This compound was prepared following the procedure described in Example 1 (part C) starting with 5 g (27.8 mmol) of 2-hydroxy-5-methyl-benzoic acid ethyl ester, 7.9 mL (55.5 mmol) of 1-bromo-2-chloro-ethane and 7.7 g (55.5 mmol) of potassium carbonate. After the work-up and purification, 4.5 g (68% of yield) of the desired product was obtained.

Workup

  1. customThis compound was prepared
  2. customAfter the work-up and purification, 4.5 g (68% of yield) of the desired product
  3. customwas obtained

Sources & evidence

ORD record
ord-11f066e0514045f082cd87e34d592195
Source dataset
uspto-grants-2004_01
Patent number
US06683096B2

Reaction notes

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