5-Methoxyindole → 5-Methoxy-3-(piperidin-4-yl)-1H-indole

HRID 1840950Notes

Reaction equation

HRID 1840950 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[CH:6]2.Cl.O.[NH:14]1[CH2:19][CH2:18][C:17](=O)[CH2:16][CH2:15]1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[CH:17]1[CH2:18][CH2:19][NH:14][CH2:15][CH2:16]1

Participants

3

Reactant 2

HCID 138725-MethoxyindoleHCID 2723901Piperonylamine

Product 1

HCID 432245-Methoxy-3-(piperidin-4-yl)-1H-indole

Procedure

This compound was prepared following the procedure described in Example 1 (parts A and B) starting with 5 g (33.9 mmol) of 5-methoxyindol and 13.2 g (86.2 mmol) of 4-piperidone monohydrate hydrochloride. After the usual work-up 6.5 g (83% of yield) of the desired product were obtained.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-958a33719ae745398d8dd5da09b83fb1
Source dataset
uspto-grants-2004_01
Patent number
US06683096B2

Reaction notes

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