5-Fluoroindole → 5-fluoro-3-(piperidin-4-yl)-1H-indole

HRID 1840955Notes

Reaction equation

HRID 1840955 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[CH:5]2.Cl.O.[NH:13]1[CH2:18][CH2:17][C:16](=O)[CH2:15][CH2:14]1>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:16]1[CH2:17][CH2:18][NH:13][CH2:14][CH2:15]1

Participants

3

Reactant 2

HCID 678615-FluoroindoleHCID 2723901Piperonylamine

Product 1

HCID 117699295-fluoro-3-(piperidin-4-yl)-1H-indole

Procedure

This compound was prepared following the procedure described in Example 1 (parts A and B) starting with 0.7 g (5.5 mmol) of 5-fluoroindol and 2.1 g (13.6 mmol) of 4-piperidone monohydrate hydrochloride. After the usual work-up 0.8 g (67% of yield) of the desired product were obtained.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-fe0eeb1995d145d5a9e718020c68c484
Source dataset
uspto-grants-2004_01
Patent number
US06683096B2

Reaction notes

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