7-Methylindole → 7-Methyl-3-(4-piperidinyl)-1H-indole

HRID 1840957Notes

Reaction equation

HRID 1840957 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][CH:8]=[CH:7]2.Cl.O.[NH:13]1[CH2:18][CH2:17][C:16](=O)[CH2:15][CH2:14]1>>[CH3:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][CH:8]=[C:7]2[CH:16]1[CH2:17][CH2:18][NH:13][CH2:14][CH2:15]1

Participants

3

Reactant 2

HCID 702757-MethylindoleHCID 2723901Piperonylamine

Product 1

HCID 112988557-Methyl-3-(4-piperidinyl)-1H-indole

Procedure

This compound was prepared following the procedure described in Example 1 (parts A and B) starting with 1 g (7.6 mmol) of 7-methylindol and 2.9 g (19 mmol) of 4-piperidone monohydrate hydrochloride. After the usual work-up 0.8 g (50% of yield) of the desired product were obtained.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-6e196de14eba4c729f7a9cc0d7ee4ccf
Source dataset
uspto-grants-2004_01
Patent number
US06683096B2

Reaction notes

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