Dichloromethane → 3-(4-(5-Amino-6-(pyridin-3-ylcarbamoyl)pyrazin-2-yl)phenyl)propyl methanesulfonate

HRID 184133Notes

Reaction equation

HRID 184133 reaction equation
[CH3:36][S:37]([Cl:38])(=[O:39])=[O:40].[CH:1]([N:2]([CH:3]([CH3:4])[CH3:5])[CH2:6][CH3:7])([CH3:8])[CH3:9].[Cl:41][CH2:42][Cl:43].[NH2:10][c:11]1[c:12]([C:27](=[O:28])[NH:29][c:30]2[cH:31][n:32][cH:33][cH:34][cH:35]2)[n:13][c:14](-[c:17]2[cH:18][cH:19][c:20]([CH2:23][CH2:24][CH2:25][OH:26])[cH:21][cH:22]2)[cH:15][n:16]1>>[NH2:10][c:11]1[c:12]([C:27](=[O:28])[NH:29][c:30]2[cH:31][n:32][cH:33][cH:34][cH:35]2)[n:13][c:14](-[c:17]2[cH:18][cH:19][c:20]([CH2:23][CH2:24][CH2:25][O:26][S:37]([CH3:36])(=[O:39])=[O:40])[cH:21][cH:22]2)[cH:15][n:16]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 31297Methanesulfonyl chlorideHCID 81531DiisopropylethylamineHCID 666790683-Amino-6-(4-(3-hydroxypropyl)phenyl)-N-(pyridin-3-yl)pyrazine-2-carboxamide

Product 1

HCID 866614883-(4-(5-Amino-6-(pyridin-3-ylcarbamoyl)pyrazin-2-yl)phenyl)propyl methanesulfonate

Sources & evidence

ORD record
ord-923c5dcab6584096875e5440428c15b4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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