Potassium Hydroxide → HCID 23445331, compound

HRID 1841395Notes

Reaction equation

HRID 1841395 reaction equation
[CH2:1]1[O:25][C:24]2[CH:23]=[CH:22][C:5](/[CH:6]=[CH:7]/[CH2:8][C:9]3[S:10][CH:11]=[CH:12][C:13]=3[S:14](N3C=CC=C3)(=[O:16])=[O:15])=[CH:4][C:3]=2[O:2]1.[OH-].[K+].S(Cl)([Cl:31])(=O)=O>C(O)(C)C>[Cl:31][S:14]([C:13]1[CH:12]=[CH:11][S:10][C:9]=1[CH2:8]/[CH:7]=[CH:6]/[C:5]1[CH:22]=[CH:23][C:24]2[O:25][CH2:1][O:2][C:3]=2[CH:4]=1)(=[O:16])=[O:15]

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 24648Sulfuryl chlorideHCID 23445564HCID 23445564, compound

Product 1

HCID 23445331HCID 23445331, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

3-chlorosulfonyl-2-[trans-3,4-(methylenedioxy)cinnamyl]thiophene was prepared in the same manner as described in Example 1 5E from N-{2-[trans-3,4-(methylenedioxy)cinnamyl]thiophene-3-sulfonyl}pyrrole by basic hydrolysis (using isopropanol and potassium hydroxide) to the corresponding potassium sulfonate (100%) followed by conversion of the salt to the corresponding sulfonyl chloride in a 31% overall yield.

Sources & evidence

ORD record
ord-75ee9f5f484f4c16a2b5a2699a64482d
Source dataset
uspto-grants-2004_01
Patent number
US06683103B2

Reaction notes

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