Lamotrigine → HCID 68929340, compound

HRID 1841436Notes

Reaction equation

HRID 1841436 reaction equation
[CH:1]1[CH:6]=[C:5]([Cl:7])[C:4]([Cl:8])=[C:3]([C:9]2[N:14]=[N:13][C:12]([NH2:15])=[N:11][C:10]=2[NH2:16])[CH:2]=1.[OH-].[Na+]>CN(C)C=O>[CH:1]1[CH:6]=[C:5]([Cl:7])[C:4]([Cl:8])=[C:3]([C:9]2[N:14]=[N:13][C:12]([NH2:15])=[N:11][C:10]=2[NH2:16])[CH:2]=1.[ClH:7]

Participants

4

Reactant 2

HCID 3878LamotrigineHCID 14798Sodium Hydroxide

Product 1

HCID 68929340HCID 68929340, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The free lamotrigine base may be obtained in nearly quantitative yield by conventional means by being released with aqueous sodium hydroxide solution in dimethylformamide.

Sources & evidence

ORD record
ord-c501c97187d8472eace9aa2b23109e2e
Source dataset
uspto-grants-2004_01
Patent number
US06683182B2

Reaction notes

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