HCID 86588089, compound → HCID 69823968, compound

HRID 1841484Notes

Reaction equation

HRID 1841484 reaction equation
[CH3:1][O:2][C:3]1[C:12]([N:13]([CH3:34])[C:14]([N:16]2[CH2:21][CH2:20][N:19]([C:22]3[CH:27]=[C:26]([N+:28]([O-])=O)[CH:25]=[C:24]([N+:31]([O-])=O)[CH:23]=3)[CH2:18][CH2:17]2)=[O:15])=[N:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1>C(O)C.[Pd]>[CH3:1][O:2][C:3]1[C:12]([N:13]([CH3:34])[C:14]([N:16]2[CH2:21][CH2:20][N:19]([C:22]3[CH:27]=[C:26]([NH2:28])[CH:25]=[C:24]([NH2:31])[CH:23]=3)[CH2:18][CH2:17]2)=[O:15])=[N:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1

Participants

4

Reactant 1

HCID 86588089HCID 86588089, compound

Product 1

HCID 69823968HCID 69823968, compoundYield 44.5%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To 1-[(2-methoxyquinoxalin-3-yl)N-methylaminocarbonyl]-4-(3,5-dinitrophenyl)piperazine dissolved in ethanol (30 ml), 10% palladium/carbon (10 mg) was added. The mixture was hydrogenated for 4 hours, and then filtered to remove the 10% palladium/carbon. The filtrate was concentrated and purified by column chromatography to obtain the titled compound.

Workup

  1. filtrationfiltered
  2. customto remove the 10% palladium/carbon
  3. concentrationThe filtrate was concentrated
  4. custompurified by column chromatography

Sources & evidence

ORD record
ord-ab56bbfeba9e425d9619fed7892240dd
Source dataset
uspto-grants-2004_01
Patent number
US06683184B2

Reaction notes

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