Ammonia → HCID 23446884, compound

HRID 1841633Notes

Reaction equation

HRID 1841633 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:14])=[C:6]2[NH:12]C(=O)O[C:8](=[O:9])[C:7]=12.[NH3:15]>CN(C=O)C.O>[NH2:12][C:6]1[C:5]([CH3:14])=[CH:4][CH:3]=[C:2]([Cl:1])[C:7]=1[C:8]([NH2:15])=[O:9]

Participants

5

Reactant 2

HCID 222AmmoniaHCID 22890221HCID 22890221, compound

Product 1

HCID 23446884HCID 23446884, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolvent2×HCID 6228DimethylformamideSolvent

Procedure

According to the procedure of example 3, in the reaction of 98.8 g (0.467 mol) of 6-chloro-3-methylisatoic anhydride in 330 ml of DMF with 42 ml (0.560 mol) of 25% strength aqueous ammonia solution in 140 ml of water and a further 110 ml of water, 24 g (37% of theory) of the title compound were obtained as a yellowish powder of m.p. 149-152° C.

Sources & evidence

ORD record
ord-c1247e73b6fd4e4eb31b1ea3e5180600
Source dataset
uspto-grants-2004_01
Patent number
US06683213B1

Reaction notes

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