Thionyl Chloride → HCID 131732407, compound

HRID 1841839Notes

Reaction equation

HRID 1841839 reaction equation
[C:1]([C@:4]1([CH2:38][OH:39])[O:10][C@@:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([CH:18]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=3)O)=[CH:14][CH:13]=2)([OH:9])[C@:7]([C:27](=[O:29])[CH3:28])([OH:26])[C@@:6]([C:31](=[O:33])[CH3:32])([OH:30])[C@@:5]1([C:35](=[O:37])[CH3:36])[OH:34])(=[O:3])[CH3:2].O=S(Cl)[Cl:42]>C(Cl)Cl>[C:1]([C@:4]1([CH2:38][OH:39])[O:10][C@@:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([CH:18]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=3)[Cl:42])=[CH:14][CH:13]=2)([OH:9])[C@:7]([C:27](=[O:29])[CH3:28])([OH:26])[C@@:6]([C:31](=[O:33])[CH3:32])([OH:30])[C@@:5]1([C:35](=[O:37])[CH3:36])[OH:34])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 131732405HCID 131732405, compound

Product 1

HCID 131732407HCID 131732407, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Tetraacetyl-(p-(pyridinylhydroxymethyl)phenoxy)-β-galactose (600 mg, 1.1 mmol) is dissolved in 15 ml of CH2Cl2. SOCl2 (143 mg, 88 μl, 1.2 mmol) is added dropwise and the solution is left stirring for 1 hour. The solvent is evaporated under vacuum. The product is obtained pure and quantitatively.

Workup

  1. waitthe solution is left
  2. customThe solvent is evaporated under vacuum
  3. customThe product is obtained pure

Sources & evidence

ORD record
ord-ce152e9ac4834ef2a1950f5e2f9b0dd4
Source dataset
uspto-grants-2015_02
Patent number
US08945514B2

Reaction notes

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