反应详情

A mixture of 12 (1.01 g, 2.75 mmol) and PtO2 (0.035 g, 0.15 mmol) in EtOH (40 mL, 95%) was shaken in a PARR apparatus under 55 p.s.i of H2 for 14 hr. The catalyst was removed by filtration through glass fiber filter paper and the solvent was removed under reduced pressure to give 13 as a pale yellow solid (0.959 g, 103%) that was used without purification. 1H NMR (400 MHz, CDCl3) δ 2.62 (tt, J=6.3, 23.9, 1H), 3.12 (dt, J=6.3, 16.2, 2H), 3.70 (d, J=1.9, 6H), 3.73 (d, J=1.9, 6H), 6.61 (d, J=8.5, 2H), 7.04 (d, J=8.5, 2H).

1. customThe catalyst was removed by filtration through glass fiber
2. filtrationfilter paper
3. customthe solvent was removed under reduced pressure